Publications

Our authored documents, platform science, neo-organ application, and other clinical information are detailed in our publications section below.

If you have any questions about our papers, please contact us.

Clinical

RENAL AUTOLOGOUS CELL THERAPY (REACT) TO STABILIZE FUNCTION IN DIABETES-RELATED CHRONIC KIDNEY DISEASE: CORROBORATION OF MECHANISM OF ACTION WITH CELL MARKER ANALYSIS

Joseph Stavas, MD, MPH, Guido Filler, MD, PhD, Deepak Jain, PhD, John Ludlow, PhD, Joydeep Basu, PhD, Richard Payne, PhD, Emily Butler, PhD, Maria Díaz-González de Ferris, MD, PhD, MPH, and Tim Bertram, PhD

Kidney Intl Reports.  April 11, 2022
DOI: https://doi.org/10.1016/j.ekir.2022.04.014

Clinical

NOVEL RENAL AUTOLOGOUS CELL THERAPY (REACT) FOR TYPE 2 DIABETES MELLITUS CHRONIC DIABETIC KIDNEY DISEASE: CLINICAL TRIAL DESIGN

Joseph Stavas, David Gerber, Steven G. Coca, Arnold L. Silva, Ashley Johns, Deepak Jain, Tim Bertram, Maria Díaz-González de Ferrise, George Bakris

American Journal of Nephrology. Jan 14, 2022
https://doi.org/10.1159/000520231

Clinical

PROTOCOL AND BASELINE DATA ON RENAL AUTOLOGOUS CELL THERAPY INJECTION IN ADULTS WITH CHRONIC KIDNEY DISEASE SECONDARY TO CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT

Joseph Stavas, Maria Diaz-Gonzalez de Ferris, Ashley Johns, Deepak Jain, Tim Bertram

Blood Purification, March 1, 2021 DOI: 10.1159/000512586

Clinical

SAFETY AND FEASIBILITY OF A NOVEL PERCUTANEOUS LOCOREGIONAL INJECTION TECHNIQUE OF RENAL CELLULAR THERAPY FOR CHRONIC KIDNEY DISEASE OF DIABETES

Hyeon Yu , Paul D. Sonntag , Peter R. Bream , Michael P. Lazarowicz, Francis S. Nowakowski, Gregory J. Woodhead, Charles T. Hennemeyer, Ryan D. Muller, Rakesh Navuluri, Elaine M. Caoili, Aaron C. Eifler, Brandon S. Tominna and Joseph M. Stavas

Clinical

RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH CHRONIC KIDNEY DISEASE

Joseph Stavas, Tim Bertram, Ashley Johns, Deepak Jain, David Gerber, Prabir Roy-Chaudhury, George Bakris

Clinical

RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH PRE-STAGE 5 CHRONIC KIDNEY DISEASE

Joseph Stavas, Tim Bertram, Deepak Jain, Ashely Johns, David Gerber, Prabir Roy-Chaudhury , George Bakris

Clinical

IMPLANTATION OF AUTOLOGOUS SELECTED RENAL CELLS IN DIABETIC CHRONIC KIDNEY DISEASE STAGES 3 AND 4—CLINICAL EXPERIENCE OF A “FIRST IN HUMAN” STUDY

Peter Stenvinkel, Jonas Wadström, Tim Bertram, Randal Detwiler, David Gerber, Torkel B. Brismar, Pontus Blomberg and Torbjörn Lundgren

Pre-Clinical

A POPULATION OF SELECTED RENAL CELLS AUGMENTS RENAL FUNCTION AND EXTENDS SURVIVAL IN THE ZSF1 MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY

Rusty Kelley, Andrew Bruce, Tom Spencer, Eric Werdin, Roger Ilagan, Sumana Choudhury, Elias Rivera, Shay Wallace, Kelly Guthrie, Manuel Jayo, Fengfeng Xu, Anjali N. Rao, Benjamin D. Humphreys, Sharon Presnell and Tim Bertram

Pre-Clinical

A TUBULAR CELL-ENRICHED SUBPOPULATION OF PRIMARY RENAL CELLS IMPROVES SURVIVAL AND AUGMENTS KIDNEY FUNCTION IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE

Kelley R., Werdin E.S., Bruce A.T., Choudhury S., Wallace S.M., Ilagan R.M., Cox B.R., Tatsumi-Ficht P., Rivera E.A., Spencer T., Rapoport H.S., Wagner B.J., Guthrie K., Jayo M.J., Bertram T.A., Presnell S.C. (2010, September 8)

Am J Physiol Renal Physiol (September 8, 2010). doi:10.1152/ajprenal.00221.2010
https://journals.physiology.org/doi/full/10.1152/ajprenal.00221.2010

Pre-Clinical

MOLECULAR CHARACTERIZATION OF THE REGENERATIVE RESPONSE INDUCED BY INTRARENAL TRANSPLANTATION OF SELECTED RENAL CELLS IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE

Genheimer, W.G., Ilagan R.M., Spencer T., Kelley R., Werdin E., Choudhury S., Jain D., Ludlow J.W., Basu J. (2012)

Cells Tissues Organs 2012;196:374–384

Pre-Clinical

FUNCTIONAL EVALUATION OF PRIMARY RENAL CELL/BIOMATERIAL NEO-KIDNEY AUGMENT PROTOTYPES FOR RENAL TISSUE ENGINEERING

Basu J., Genheimer C.W., Rivera E.A., Payne R., Mihalko K., Guthrie K., Bruce A.T., Robbins N., McCoy D., Sangha N., Ilagan R., Knight T., Spencer T., Wagner B.J., Jayo M.J., Jain D., Ludlow J.W., Halberstadt C. (2011, March)

Cell Transplant. 2011 Mar 24. doi: 10.3727/096368911X566172
http://www.ncbi.nlm.nih.gov/pubmed/21439130

Pre-Clinical

ISOLATION, CHARACTERIZATION, AND EXPANSION (ICE) METHODS FOR DEFINED PRIMARY RENAL CELL POPULATIONS FROM RODENT, CANINE, AND HUMAN NORMAL AND DISEASED KIDNEYS

Presnell S.C., Bruce A.T., Wallace S.M., Choudhury S., Genheimer C., Cox B., Guthrie K.I., Werdin E.S., Tatsumi-Ficht P., Ilagan R., Kelley R.W., Rivera E.A., Ludlow J.W., Wagner B.J., Jayo M.J., Bertram T. (2010, September 16)

Tissue Eng Part C Methods. 2010 Sep 16
http://www.ncbi.nlm.nih.gov/pubmed/20846053