Our authored documents, platform science, neo-organ application, and other clinical information are detailed in our publications section below.
If you have any questions about our papers, please contact us.
Clinical
Renal Autologous Cell Therapy in Type 2 Diabetes with Late Stage 4 Diabetes-Related Chronic Kidney Disease: Trial Design and Early Analysis
Joseph Stavas, Bijin Thajudeen, Steven Coca, Arnold Silva, Emily Butler, Randal Detwiler, Anna Burgner
Blood Purification. January 4, 2023
PRE-Clinical
Selected Renal Cells Harbor Nephrogenic Potential
Prakash Narayan, Andrew T. Bruce, Elias A. Rivera, Timothy A. Bertram, Deepak Jain
Frontiers in Medicine. December 22, 2022
pre-Clinical
GENE ONTOLOGY REVEALS POTENTIALLY UNIQUE MECHANISM OF ACTION UNDERLYING SELECTED RENAL CELLS BIOACTIVITY
Prakash Narayan, Joseph Stavas, Timothy A. Bertram and Deepak Jain
Poster at ASN 2022 Annual Meeting: November 4, 2022
NON-Clinical
SGLT2i PRESCRIBERS AMONG CHRONIC KIDNEY DISEASE (CKD) PATIENTS: TRENDS IN REAL-WORLD DATA (RWD)
Joseph Stavas, Emily Butler, Jenna Abdelhadi, Tancy C. Zhang, Lexie Rubens, Libbie McKenzie, Debra Irwin
Poster at ASN 2022 Annual Meeting: November 4, 2022
NON-Clinical
GENDER DIFFERENCES IN CHRONIC KIDNEY DISEASE PROGRESSION: REAL-WORLD DATA (RWD) ANALYSIS
Joseph Stavas, Guido Filler, Debra Irwin, Kate Lovett, Rohan Shah, Emily Butler, Libbie McKenzie, Maria Ferris
Poster at ASN 2022 Annual Meeting: November 4, 2022
pre-Clinical
SELECTED RENAL CELLS SELF-ORGANIZE TO FORM NEO-NEPHRONS AND ATTENUATE KIDNEY DISEASE
Prakash Narayan, Elias A. Rivera, Deepak Jain, Timothy A. Bertram, John W. Ludlow and Joydeep Basu
Poster at ASN 2022 Annual Meeting: November 4, 2022
NON-Clinical
PREVALENCE OF CHRONIC KIDNEY DISEASE (CKD): COMPARISON OF REAL-WORLD DATA (RWD) SOURCES TO THE USA NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES)
Joseph Stavas, Emily Butler, Debra Irwin, Rohan Shah, Helen Latimer, Alberto Sepulveda, Sandy Balkin, Libbie McKenzie, Katherine R. Tuttle
Poster at ASN 2022 Annual Meeting: November 3, 2022
Clinical
RENAL AUTOLOGOUS CELL THERAPY (REACT) TO STABILIZE FUNCTION IN DIABETES-RELATED CHRONIC KIDNEY DISEASE: CORROBORATION OF MECHANISM OF ACTION WITH CELL MARKER ANALYSIS
Joseph Stavas, MD, MPH, Guido Filler, MD, PhD, Deepak Jain, PhD, John Ludlow, PhD, Joydeep Basu, PhD, Richard Payne, PhD, Emily Butler, PhD, Maria Díaz-González de Ferris, MD, PhD, MPH, and Tim Bertram, PhD
Kidney Intl Reports. April 11, 2022
DOI: https://doi.org/10.1016/j.ekir.2022.04.014
Clinical
NOVEL RENAL AUTOLOGOUS CELL THERAPY (REACT) FOR TYPE 2 DIABETES MELLITUS CHRONIC DIABETIC KIDNEY DISEASE: CLINICAL TRIAL DESIGN
Joseph Stavas, David Gerber, Steven G. Coca, Arnold L. Silva, Ashley Johns, Deepak Jain, Tim Bertram, Maria Díaz-González de Ferrise, George Bakris
American Journal of Nephrology. Jan 14, 2022
https://doi.org/10.1159/000520231
Clinical
PROTOCOL AND BASELINE DATA ON RENAL AUTOLOGOUS CELL THERAPY INJECTION IN ADULTS WITH CHRONIC KIDNEY DISEASE SECONDARY TO CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT
Joseph Stavas, Maria Diaz-Gonzalez de Ferris, Ashley Johns, Deepak Jain, Tim Bertram
Blood Purification, March 1, 2021 DOI: 10.1159/000512586
Clinical
SAFETY AND FEASIBILITY OF A NOVEL PERCUTANEOUS LOCOREGIONAL INJECTION TECHNIQUE OF RENAL CELLULAR THERAPY FOR CHRONIC KIDNEY DISEASE OF DIABETES
Hyeon Yu , Paul D. Sonntag , Peter R. Bream , Michael P. Lazarowicz, Francis S. Nowakowski, Gregory J. Woodhead, Charles T. Hennemeyer, Ryan D. Muller, Rakesh Navuluri, Elaine M. Caoili, Aaron C. Eifler, Brandon S. Tominna and Joseph M. Stavas
Clinical
RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH CHRONIC KIDNEY DISEASE
Joseph Stavas, Tim Bertram, Ashley Johns, Deepak Jain, David Gerber, Prabir Roy-Chaudhury, George Bakris
Clinical
RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH PRE-STAGE 5 CHRONIC KIDNEY DISEASE
Joseph Stavas, Tim Bertram, Deepak Jain, Ashely Johns, David Gerber, Prabir Roy-Chaudhury , George Bakris
Clinical
IMPLANTATION OF AUTOLOGOUS SELECTED RENAL CELLS IN DIABETIC CHRONIC KIDNEY DISEASE STAGES 3 AND 4—CLINICAL EXPERIENCE OF A “FIRST IN HUMAN” STUDY
Peter Stenvinkel, Jonas Wadström, Tim Bertram, Randal Detwiler, David Gerber, Torkel B. Brismar, Pontus Blomberg and Torbjörn Lundgren
Pre-Clinical
A POPULATION OF SELECTED RENAL CELLS AUGMENTS RENAL FUNCTION AND EXTENDS SURVIVAL IN THE ZSF1 MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY
Rusty Kelley, Andrew Bruce, Tom Spencer, Eric Werdin, Roger Ilagan, Sumana Choudhury, Elias Rivera, Shay Wallace, Kelly Guthrie, Manuel Jayo, Fengfeng Xu, Anjali N. Rao, Benjamin D. Humphreys, Sharon Presnell and Tim Bertram
Pre-Clinical
A TUBULAR CELL-ENRICHED SUBPOPULATION OF PRIMARY RENAL CELLS IMPROVES SURVIVAL AND AUGMENTS KIDNEY FUNCTION IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE
Kelley R., Werdin E.S., Bruce A.T., Choudhury S., Wallace S.M., Ilagan R.M., Cox B.R., Tatsumi-Ficht P., Rivera E.A., Spencer T., Rapoport H.S., Wagner B.J., Guthrie K., Jayo M.J., Bertram T.A., Presnell S.C. (2010, September 8)
Am J Physiol Renal Physiol (September 8, 2010). doi:10.1152/ajprenal.00221.2010
https://journals.physiology.org/doi/full/10.1152/ajprenal.00221.2010
Pre-Clinical
MOLECULAR CHARACTERIZATION OF THE REGENERATIVE RESPONSE INDUCED BY INTRARENAL TRANSPLANTATION OF SELECTED RENAL CELLS IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE
Genheimer, W.G., Ilagan R.M., Spencer T., Kelley R., Werdin E., Choudhury S., Jain D., Ludlow J.W., Basu J. (2012)
Cells Tissues Organs 2012;196:374–384
Pre-Clinical
FUNCTIONAL EVALUATION OF PRIMARY RENAL CELL/BIOMATERIAL NEO-KIDNEY AUGMENT PROTOTYPES FOR RENAL TISSUE ENGINEERING
Basu J., Genheimer C.W., Rivera E.A., Payne R., Mihalko K., Guthrie K., Bruce A.T., Robbins N., McCoy D., Sangha N., Ilagan R., Knight T., Spencer T., Wagner B.J., Jayo M.J., Jain D., Ludlow J.W., Halberstadt C. (2011, March)
Cell Transplant. 2011 Mar 24. doi: 10.3727/096368911X566172
http://www.ncbi.nlm.nih.gov/pubmed/21439130
Pre-Clinical
ISOLATION, CHARACTERIZATION, AND EXPANSION (ICE) METHODS FOR DEFINED PRIMARY RENAL CELL POPULATIONS FROM RODENT, CANINE, AND HUMAN NORMAL AND DISEASED KIDNEYS
Presnell S.C., Bruce A.T., Wallace S.M., Choudhury S., Genheimer C., Cox B., Guthrie K.I., Werdin E.S., Tatsumi-Ficht P., Ilagan R., Kelley R.W., Rivera E.A., Ludlow J.W., Wagner B.J., Jayo M.J., Bertram T. (2010, September 16)
Tissue Eng Part C Methods. 2010 Sep 16
http://www.ncbi.nlm.nih.gov/pubmed/20846053