Our authored documents, platform science, neo-organ application, and other clinical information are detailed in our publications section below.
If you have any questions about our papers, please contact us.
Clinical
Renal Autologous Cell Therapy Candidate Promotes Functional Cellular Adaptation Under Persistent Injury Conditions
Caryn Cloer, Michael Czerwinski, Melina Lillich, Andrew Bruce, Eric Labonte, Anthony Conway
Presentation at 63rd ERA Congress: June 3 – 6, 2026
Clinical
A Randomized Clinical Trial of Kidney Autologous Cell Therapy in Diabetic Kidney Disease
Borut Čižman, Emily Butler, Joseph Stavas, Rachita Prakash, Theodore Saad, Arnold Silva, Thomas Wooldridge, Ahmed Aqeel, Hongxia Yan, Constance Barysauskas, Bruce Culleton
Clinical Journal of the American Society of Nephrology: Jan 2, 2026
Clinical
Cell-Specific Inflammatory Profile Characterization of the Cell Therapy Candidate Rilparencel
Katherine James, Ashley Greenawalt, Mark Rohlfing, Max Xu, Andrew Bruce, Dominic Justewicz
Presentation at American Society of Nephrology Kidney Week 2025: Nov 6 – 9, 2025
Clinical
Renal Autologous Cell Therapy in Diabetes and CKD
Bruce Culleton, Emily Butler, Ahmed Aqeel, Rachita Prakash, Theodore Saad, Arnold Silva, Thomas Wooldridge, Hongxia Yan, Constance Barysauskas, Joseph Stavas, Borut Cizman
Presentation at American Society of Nephrology Kidney Week 2025: Nov 6 – 9, 2025
Clinical
Late Clinical-Stage Candidate Rilparencel’s Effect on Kidney Function and Biological Pathways in a Type 2 Diabetes and Chronic Kidney Patient Subset
Prakash Narayan, Courtney Luterbach, Brooke Bauer, Guido Filler, Benjamin S. Freedman, Howard Trachtman, Joseph Stavas, Emily Butler, Andrew Bruce
Presentation at American Society of Nephrology Kidney Week 2024: Oct 24 – 27, 2024
Clinical
The Phase 3 Clinical Candidate Rilparencel Demonstrates Distinct Secretomic Signatures at Key Points in Manufacturing which Suggest a Reduced Inflammatory and Fibrotic Profile
Ashley Greenawalt, Mark Rohlfing, Brooke Bauer, Andrew Bruce, Dominic Justewicz
Presentation at American Society of Nephrology Kidney Week 2024: Oct 24 – 27, 2024
Clinical
Rilparencel Autologous Cell Therapy in Patients with Diabetes and Advanced Chronic Kidney Disease: Phase 2 Interim Results The Phase 3 Clinical Candidate Rilparencel Demonstrates Weak Association with Renal Epithelial SASP
Mark Rohlfing, Ashley Greenawalt, Brooke Bauer, Andrew Bruce, Dominic Justewicz
Presentation at American Society of Nephrology Kidney Week 2024: Oct 24 – 27, 2024
Clinical
Rilparencel Autologous Cell Therapy in Patients with Diabetes and Advanced Chronic Kidney Disease: Phase 2 Interim Results
Joseph Stavas, Arnold Silva, Theodore Saad, Emily Butler, Navdeep Tangri, Bruce Culleton
Presentation at American Society of Nephrology Kidney Week 2024: Oct 24 – 27, 2024
Clinical
The Phase 3 Clinical Trial Candidate Rilparencel Shows Distinct Phenotypic Characteristics During Product Manufacture
Evan D. Trudeau, Andrew T. Bruce, Dominic M. Justewicz
Presentation at American Society of Nephrology Kidney Week 2024: Oct 24 – 27, 2024
Clinical
Rilparencel Renal Autologous Cell Therapy for Patients with Stage 3-4 CKD and Type 2 Diabetes: Results from a Phase 2 Clinical Trial
David Gerber, George Bakris, Arnold Silva, Steven Coca, Anna Burgner, Emily Butler, Bruce Culleton, Joseph Stavas
Presentation at 61st ERA Congress: May 23 – 26, 2024
Clinical
Renal Autologous Cell Therapy (REACT®) to Delay Dialysis in Advanced Chronic Kidney Disease
Joseph Stavas, Bijin Thajudeen, Steven G. Coca, Randal K. Detwiler, Arnold L. Silva, Johnna D. Anderson, Anna M. Burgner
Poster at ASN 2023 Annual Meeting: November 2, 2023
Non-Clinical
Selected Renal Cells Express a Podocyte-Parietal Epithelial Cell Transcriptome
Prakash Narayan, Andrew T. Bruce, Mark A. Rohlfing, Timothy A. Bertram and Deepak Jain
Poster at ASN 2023 Annual Meeting: November 2, 2023
Non-Clinical
Selected Renal Cells Exhibit Renal Tubule Formation Associated with Transforming Growth Factor B2 Expression
Prakash Narayan, Andrew T. Bruce, Mark A. Rohlfing, Timothy A. Bertram and Deepak Jain
Poster at ASN 2023 Annual Meeting: November 3, 2023
Non-Clinical
Selected Renal Cells Improve Renal Function in a Canine Model of Chronic Kidney Disease
Prakash Narayan, Andrew T. Bruce, Elias A. Rivera, Timothy A. Bertram and Deepak Jain
Poster at ASN 2023 Annual Meeting: November 4, 2023
Clinical
Renal Autologous Cell Therapy (REACT®) for Diabetic Chronic Kidney Disease: REGEN-007 Phase II Trial Evaluating Bilateral Cortex Injections and Re-Dosing Trigger
Joseph Stavas, Arnold Silva, Ahmed Aqeel, Rachita Prakash, Melissa Yanover, Tom Woolridge, Kerry Cooper
Poster at 60th ERA Congress: June 15-18, 2023
Clinical
Renal Autologous Cell Therapy in Type 2 Diabetes with Late Stage 4 Diabetes-Related Chronic Kidney Disease: Trial Design and Early Analysis
Joseph Stavas, Bijin Thajudeen, Steven Coca, Arnold Silva, Emily Butler, Randal Detwiler, Anna Burgner
Blood Purification. January 4, 2023
PRE-Clinical
Selected Renal Cells Harbor Nephrogenic Potential
Prakash Narayan, Andrew T. Bruce, Elias A. Rivera, Timothy A. Bertram, Deepak Jain
Frontiers in Medicine. December 22, 2022
pre-Clinical
GENE ONTOLOGY REVEALS POTENTIALLY UNIQUE MECHANISM OF ACTION UNDERLYING SELECTED RENAL CELLS BIOACTIVITY
Prakash Narayan, Joseph Stavas, Timothy A. Bertram and Deepak Jain
Poster at ASN 2022 Annual Meeting: November 2, 2023
NON-Clinical
SGLT2i PRESCRIBERS AMONG CHRONIC KIDNEY DISEASE (CKD) PATIENTS: TRENDS IN REAL-WORLD DATA (RWD)
Joseph Stavas, Emily Butler, Jenna Abdelhadi, Tancy C. Zhang, Lexie Rubens, Libbie McKenzie, Debra Irwin
Poster at ASN 2022 Annual Meeting: November 4, 2022
NON-Clinical
GENDER DIFFERENCES IN CHRONIC KIDNEY DISEASE PROGRESSION: REAL-WORLD DATA (RWD) ANALYSIS
Joseph Stavas, Guido Filler, Debra Irwin, Kate Lovett, Rohan Shah, Emily Butler, Libbie McKenzie, Maria Ferris
Poster at ASN 2022 Annual Meeting: November 4, 2022
pre-Clinical
SELECTED RENAL CELLS SELF-ORGANIZE TO FORM NEO-NEPHRONS AND ATTENUATE KIDNEY DISEASE
Prakash Narayan, Elias A. Rivera, Deepak Jain, Timothy A. Bertram, John W. Ludlow and Joydeep Basu
Poster at ASN 2022 Annual Meeting: November 4, 2022
NON-Clinical
PREVALENCE OF CHRONIC KIDNEY DISEASE (CKD): COMPARISON OF REAL-WORLD DATA (RWD) SOURCES TO THE USA NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES)
Joseph Stavas, Emily Butler, Debra Irwin, Rohan Shah, Helen Latimer, Alberto Sepulveda, Sandy Balkin, Libbie McKenzie, Katherine R. Tuttle
Poster at ASN 2022 Annual Meeting: November 3, 2022
Clinical
RENAL AUTOLOGOUS CELL THERAPY (REACT) TO STABILIZE FUNCTION IN DIABETES-RELATED CHRONIC KIDNEY DISEASE: CORROBORATION OF MECHANISM OF ACTION WITH CELL MARKER ANALYSIS
Joseph Stavas, MD, MPH, Guido Filler, MD, PhD, Deepak Jain, PhD, John Ludlow, PhD, Joydeep Basu, PhD, Richard Payne, PhD, Emily Butler, PhD, Maria Díaz-González de Ferris, MD, PhD, MPH, and Tim Bertram, PhD
Kidney Intl Reports. April 11, 2022
DOI: https://doi.org/10.1016/j.ekir.2022.04.014
Clinical
NOVEL RENAL AUTOLOGOUS CELL THERAPY (REACT) FOR TYPE 2 DIABETES MELLITUS CHRONIC DIABETIC KIDNEY DISEASE: CLINICAL TRIAL DESIGN
Joseph Stavas, David Gerber, Steven G. Coca, Arnold L. Silva, Ashley Johns, Deepak Jain, Tim Bertram, Maria Díaz-González de Ferrise, George Bakris
American Journal of Nephrology. Jan 14, 2022
https://doi.org/10.1159/000520231
Clinical
PROTOCOL AND BASELINE DATA ON RENAL AUTOLOGOUS CELL THERAPY INJECTION IN ADULTS WITH CHRONIC KIDNEY DISEASE SECONDARY TO CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT
Joseph Stavas, Maria Diaz-Gonzalez de Ferris, Ashley Johns, Deepak Jain, Tim Bertram
Blood Purification, March 1, 2021 DOI: 10.1159/000512586
Clinical
SAFETY AND FEASIBILITY OF A NOVEL PERCUTANEOUS LOCOREGIONAL INJECTION TECHNIQUE OF RENAL CELL THERAPY FOR CHRONIC KIDNEY DISEASE OF DIABETES
Hyeon Yu , Paul D. Sonntag , Peter R. Bream , Michael P. Lazarowicz, Francis S. Nowakowski, Gregory J. Woodhead, Charles T. Hennemeyer, Ryan D. Muller, Rakesh Navuluri, Elaine M. Caoili, Aaron C. Eifler, Brandon S. Tominna and Joseph M. Stavas
Clinical
RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH CHRONIC KIDNEY DISEASE
Joseph Stavas, Tim Bertram, Ashley Johns, Deepak Jain, David Gerber, Prabir Roy-Chaudhury, George Bakris
Clinical
RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT™ (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN TYPE 2 DIABETES WITH PRE-STAGE 5 CHRONIC KIDNEY DISEASE
Joseph Stavas, Tim Bertram, Deepak Jain, Ashely Johns, David Gerber, Prabir Roy-Chaudhury , George Bakris
Clinical
IMPLANTATION OF AUTOLOGOUS SELECTED RENAL CELLS IN DIABETIC CHRONIC KIDNEY DISEASE STAGES 3 AND 4—CLINICAL EXPERIENCE OF A “FIRST IN HUMAN” STUDY
Peter Stenvinkel, Jonas Wadström, Tim Bertram, Randal Detwiler, David Gerber, Torkel B. Brismar, Pontus Blomberg and Torbjörn Lundgren
Pre-Clinical
A POPULATION OF SELECTED RENAL CELLS AUGMENTS RENAL FUNCTION AND EXTENDS SURVIVAL IN THE ZSF1 MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY
Rusty Kelley, Andrew Bruce, Tom Spencer, Eric Werdin, Roger Ilagan, Sumana Choudhury, Elias Rivera, Shay Wallace, Kelly Guthrie, Manuel Jayo, Fengfeng Xu, Anjali N. Rao, Benjamin D. Humphreys, Sharon Presnell and Tim Bertram
Pre-Clinical
A TUBULAR CELL-ENRICHED SUBPOPULATION OF PRIMARY RENAL CELLS IMPROVES SURVIVAL AND AUGMENTS KIDNEY FUNCTION IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE
Kelley R., Werdin E.S., Bruce A.T., Choudhury S., Wallace S.M., Ilagan R.M., Cox B.R., Tatsumi-Ficht P., Rivera E.A., Spencer T., Rapoport H.S., Wagner B.J., Guthrie K., Jayo M.J., Bertram T.A., Presnell S.C. (2010, September 8)
Am J Physiol Renal Physiol (September 8, 2010). doi:10.1152/ajprenal.00221.2010
https://journals.physiology.org/doi/full/10.1152/ajprenal.00221.2010
Pre-Clinical
MOLECULAR CHARACTERIZATION OF THE REGENERATIVE RESPONSE INDUCED BY INTRARENAL TRANSPLANTATION OF SELECTED RENAL CELLS IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE
Genheimer, W.G., Ilagan R.M., Spencer T., Kelley R., Werdin E., Choudhury S., Jain D., Ludlow J.W., Basu J. (2012)
Cells Tissues Organs 2012;196:374–384
Pre-Clinical
FUNCTIONAL EVALUATION OF PRIMARY RENAL CELL/BIOMATERIAL NEO-KIDNEY AUGMENT PROTOTYPES FOR RENAL TISSUE ENGINEERING
Basu J., Genheimer C.W., Rivera E.A., Payne R., Mihalko K., Guthrie K., Bruce A.T., Robbins N., McCoy D., Sangha N., Ilagan R., Knight T., Spencer T., Wagner B.J., Jayo M.J., Jain D., Ludlow J.W., Halberstadt C. (2011, March)
Cell Transplant. 2011 Mar 24. doi: 10.3727/096368911X566172
http://www.ncbi.nlm.nih.gov/pubmed/21439130
Pre-Clinical
ISOLATION, CHARACTERIZATION, AND EXPANSION (ICE) METHODS FOR DEFINED PRIMARY RENAL CELL POPULATIONS FROM RODENT, CANINE, AND HUMAN NORMAL AND DISEASED KIDNEYS
Presnell S.C., Bruce A.T., Wallace S.M., Choudhury S., Genheimer C., Cox B., Guthrie K.I., Werdin E.S., Tatsumi-Ficht P., Ilagan R., Kelley R.W., Rivera E.A., Ludlow J.W., Wagner B.J., Jayo M.J., Bertram T. (2010, September 16)
Tissue Eng Part C Methods. 2010 Sep 16
http://www.ncbi.nlm.nih.gov/pubmed/20846053
